Discovering Treatments & Cures Through Innovative Translational Research

Beauty is not the only thing that lies in the eye of the beholder. Stress, too, has both perceived and real components, and like beauty, the concept of stress has evolved. I believe that the stress axis, as described by Hans Seyle, which involves the neurohormonal activation of the hypothalamic-pituitary-adrenal (HPA) axis, is constantly in "overdrive" for many people today. While some stress actually benefits the organism as a whole, this constant state of being in a perceived state of stress exacerbates myriad disease symptoms. The CRF system, the main driving force behind the HPA axis influences immune and non-immune cellular responses locally in the peripheral tissues that are distinct from those mediated by the action of CRF in the CNS.

Recent Publications

Xi Y, Wei Y, Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM, Jablons DM, Chapman HA
Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia.
Oncogene, Dec-17-2012; [Epub ahead of print].
Cottrell GS, Alemi F, Kirkland JG, Grady EF, Corvera CU, Bhargava A
Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract.
Peptides, Jun-01-2012; 352: 202-11.  Epub 2012 Mar 30.
Hasdemir B, Mahajan S, Bunnett NW, Liao M, Bhargava A
Endothelin-converting enzyme-1 actions determine differential trafficking and signaling of corticotropin-releasing factor receptor 1 at high agonist concentrations.
Molecular endocrinology (Baltimore, Md.), Apr-01-2012; 264: 681-95.  Epub 2012 Feb 9.
Chang J, Adams MR, Clifton MS, Liao M, Brooks JH, Hasdemir B, Bhargava A
Urocortin 1 modulates immunosignaling in a rat model of colitis via corticotropin-releasing factor receptor 2.
American journal of physiology. Gastrointestinal and liver physiology, May-01-2011; 3005: G884-94.  Epub 2011 Feb 17.
Liu L, Li Q, Sapolsky R, Liao M, Mehta K, Bhargava A, Pasricha PJ
Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults.
PloS one, [epublish] 65: e19498.
Pao AC, Bhargava A, Di Sole F, Quigley R, Shao X, Wang J, Thomas S, Zhang J, Shi M, Funder JW, Moe OW, Pearce D
Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney.
American journal of physiology. Renal physiology, Dec-01-2010; 2996: F1496-506.  Epub 2010 Oct 6.
Jasmin L, Vit JP, Bhargava A, Ohara PT
Can satellite glial cells be therapeutic targets for pain control?.
Neuron glia biology, Feb-01-2010; 61: 63-71.  Epub 2010 Jun 22.
Cureton EL, Ereso AQ, Victorino GP, Curran B, Poole DP, Liao M, Harken AH, Bhargava A
Local secretion of urocortin 1 promotes microvascular permeability during lipopolysaccharide-induced inflammation.
Endocrinology, Dec-01-2009; 15012: 5428-37.  Epub 2009 Oct 9.
Vit JP, Ohara PT, Bhargava A, Kelley K, Jasmin L
Silencing the Kir4.1 potassium channel subunit in satellite glial cells of the rat trigeminal ganglion results in pain-like behavior in the absence of nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience, Apr-16-2008; 2816: 4161-71.
Bhargava A, Dallman MF, Pearce D, Choi S
Long double-stranded RNA-mediated RNA interference as a tool to achieve site-specific silencing of hypothalamic neuropeptides.
Brain research. Brain research protocols, Jun-01-2004; 132: 115-25.
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